Tuesday, November 23, 2010

cyclophosphamide, epirubicin, and fluorouracil

Epirubicin is an anthracycline drug used for chemotherapy.

Similarly to other anthracyclines, epirubicin acts by inhibiting DNA and RNA synthesis. It also triggers DNA cleavage by topoisomerase II, resulting in mechanisms that lead to cell death. Binding to cell membranes and plasma proteins may be involved in the compound's cytotoxic effects. Epirubicin also generates free radicals that cause cell and DNA damage.

The most serious side effect is heart damage.

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