Brachial nerves -- from the lower neck and upper chest -- become irritated or damaged, causing mild discomfort in the shoulder and arm.
Factors that MAY increase the risk of developing brachial plexopathy include a higher dose of radiation, a larger treatment area, young age, and CMF chemotherapy (cyclophosphamide, methotrexate, 5-FU) given at the same time as radiation.
Other symptoms include numbness, tingling, or burning sensation as well as weakness of the arm and hand. Brachial plexopathy is rare.
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